Platelet inhibitors influence cardioprotection: importance in preclinical study design: reply

Platelet inhibitors influence cardioprotection: importance in preclinical study design: reply.

Platelet recovery in dengue--a reply.

Design of new potent HTLV-1 protease inhibitors: in silico study

HTLV-1 and HIV-1 are two major causes for severe T-cell leukemia disease and acquired immune deficiency syndrome (AIDS). HTLV-1 protease, a member of aspartic acid protease family, plays important roles in maturation during virus replication cycle. The impairment of these proteases results in uninfectious HTLV-1virions.Similar to HIV-1protease deliberate mutations that confer drug resistance on...

PARP inhibitors for chemoprevention--reply.

We thank Brody and colleagues (1) for their thoughtful letter that raised three major issues about PARP inhibitors for chemoprevention: (i) long-term toxicity, (ii) secondary tumors, and (iii) drug resistance. We appreciate their desire to open a dialogue, as we agree that these important challenges must be addressed. Whether low doses of platinum-based compounds are effective in our animal mod...

Importance of Preclinical Imaging in Drug Discovery

The process of discovering and bringing a drug to market consists of several stages, beginning with identification and validation of a drug target and continuing through lead identification by high-throughput screening, lead optimization, and profiling in relevant disease models. When a promising compound is found, a decision must be made on whether to take the drug into development. This long ...